Protein Modification Reagents
Medchemexpress LLC t-Boc-N-amido-PEG5-acetic acid | 890152-41-7 | MFCD31656900 | 99.9% | 395.45 g/mol | C17H33NO9 | 50 MG
t-Boc-N-amido-PEG5-acetic acid is a Boc-protected PEG5 linker terminating in an acetic acid functional group intended for use in targeted protein degrader (PROTAC) synthesis. It provides a flexible, water-soluble spacer and a masked amine for selective functionalization, facilitating linker optimization and efficient conjugation in medicinal chemistry workflows.
- Boc-protected amine for controlled deprotection and downstream derivatization.
- PEG5 spacer provides flexibility and improved aqueous solubility.
- Terminal acetic acid enables standard amide coupling chemistries.
- High purity supports reproducible coupling and characterization.
- Available in laboratory-scale quantities suitable for synthesis optimization.
Medchemexpress LLC Dspe-peg-cooh, mw 2000 | 1403744-37-5 | 100.0% | 2000 Da | C50H94N2NaO14P | 1 MG
DSPE-PEG-COOH (MW 2000) is a PEGylated phospholipid composed of distearoylphosphatidylethanolamine linked to an approximately 2,000 Da polyethylene glycol chain terminating in a carboxylic acid. It is supplied as a white to off-white solid and is used for liposome and nanoparticle formulation and for surface functionalization via amide coupling.
- Terminal carboxylic acid suitable for amide coupling to primary amines.
- Average molecular weight ~2,000 Da provides PEG spacer functionality.
- Facilitates formation of stable, stealth liposomes and nanoparticles.
- White to off-white solid compatible with common organic solvents.
- High reported purity for reproducible formulation and analysis.
eMolecules 1085938-09-5 | Medchem Express | Biotin-PEG6-azide | 25mg | 722714309 | HY-140911 | 576.71 | C24H44N6O8S
Medchem Express | N-Hydroxypipecolic acid | 5mg | 515744488 | HY-N7378 | 115819-92-6 | MFCD13179004 | 145.158 | C6H11NO3
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Medchemexpress LLC TCO-PEG4-NHS ester | 1621096-79-4 | 99.2% | C24H38N2O10 | 50 MG
TCO-PEG4-NHS ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It also functions as a click chemistry reagent, capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. This reagent facilitates the creation of PROTACs, which leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a TCO group
- Undergoes inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine groups
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG5-amine | 113072-75-6 | 96.2% | C22H42N4O7S | 25 MG
Biotin-PEG5-amine | 113072-75-6 | 96.2% | C22H42N4O7S | 25 MG
Medchemexpress LLC DSPE-PEG2000-Maleimide | 99.6% | 50 MG
DSPE-PEG2000-Maleimide is a phospholipid-PEG conjugate. It utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. This product covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, which provides targeting capabilities to the particles. It can be used in research related to breast cancer, lymphoma, and inherited retinal degeneration.
- Used to prepare targeted liposomes (TLPD).
![eMolecules 940005-81-2 | Bromoacetamido-PEG3-azide | Broadpharm | MFCD22683302 | 339.190 | C10H19BrN4O4 | 0.000 | BrCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 1g | 200183383](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502202985.JPG-250.jpg)
eMolecules 940005-81-2 | Bromoacetamido-PEG3-azide | Broadpharm | MFCD22683302 | 339.190 | C10H19BrN4O4 | 0.000 | BrCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 1g | 200183383
Bromoacetamido-PEG3-azide | Broadpharm | 940005-81-2 | MFCD22683302 | 339.190 | C10H19BrN4O4 | 0.000 | BrCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 1g | 200183383
Medchemexpress LLC Biotin-PEG4-azide | 1309649-57-7 | 99.8% | C20H36N6O6S | 25 MG
Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, facilitating both copper-catalyzed and strain-promoted cycloaddition reactions.
- Biotin-labeled and PEG-based PROTAC linker
- Essential for PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC HO-PEG24-OH | 2243942-52-9 | 99.9% | C48H98O25 | 50 MG
HO-PEG24-OH is a high-purity, polyethylene glycol (PEG)-based PROTAC linker with a purity of 99.89%. This linker is specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs), providing a versatile building block for targeted protein degradation research.
- Peg-based linker
- Designed for PROTAC synthesis
- High purity for research applications
- Supports targeted protein degradation studies
Medchemexpress LLC M-PEG-C1-DSPE sodium (MW 1000) | 1000 | 500 MG
M-PEG-C1-DSPE sodium (MW 1000) is a PEG lipid and a structural analog of m-PEG-DSPE sodium (MW 1000) (HY-W440922). It can improve the delivery efficiency and tissue specificity of poorly soluble drugs.
- Enhances delivery efficiency of poorly soluble drugs.
- Enhances tissue specificity of poorly soluble drugs.
- Suitable for use in drug delivery research.
Medchemexpress LLC Biotin-PEG6-azide | 1085938-09-5 | 99.9% | C24H44N6O8S | 25 MG
Biotin-PEG6-azide is a biotin-labeled, PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs and functions as a click chemistry reagent, facilitating targeted protein degradation applications.
- Biotin-labeled for detection and purification
- PEG-based for improved solubility and reduced immunogenicity
- PROTAC linker for targeted protein degradation
- Click chemistry reagent for efficient conjugation
eMolecules Mal-amido-PEG23-amine | Broadpharm |1224.440 | C55H105N3O26 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 599128868
Mal-amido-PEG23-amine | Broadpharm |1224.440 | C55H105N3O26 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 599128868